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Target intelligence / Profile preview
Mitogen-activated Protein Kinase 12 (MAPK12)
- Target
- MAPK12
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAPK, p38 MAPK
01
Overview
Mitogen-activated protein kinase 12 (MAPK12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is a serine/threonine protein kinase that belongs to the p38 MAPK subfamily. It functions primarily as a signal transducer during muscle cell differentiation and plays a critical role in cellular responses to extracellular stimuli such as pro-inflammatory cytokines and physical stress.
- Other names
- ERK6ERK3P38GAMMAPRKM12SAPK3SAPK-3Extracellular signal-regulated kinase 6Stress-activated protein kinase 3
02
Mechanism of action
Dual phosphorylation within the activation loop at specific threonine and tyrosine residues
03
Biological functions
Signal transductionRegulation of transcription (DNA-templated)Phosphorylation of target proteinsPositive regulation of muscle cell differentiationMuscle organ developmentMyoblast differentiationPeptidyl-serine phosphorylationStress responseInflammatory response
04
Disease associations
Muscular disordersInflammation
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