Mitogen-activated protein kinase 6 (MAPK6 (often also called ERK3))

Mitogen-activated protein kinase 6 is an atypical serine/threonine protein kinase belonging to the MAPK (mitogen-activated protein kinase) family, encoded by the MAPK6 gene in humans. Unlike classical MAPKs, MAPK6 (also known as ERK3) features distinct structural and regulatory properties, including a unique phosphorylation motif and extended regulatory regions. MAPK6 is primarily located in the nucleus and is involved in the integration of multiple biochemical signaling pathways in response to external stimuli. Recent insights from crystal structure analysis highlight its distinct ATP-binding pocket, creating opportunities for selective drug development. Although the full spectrum of its biological roles remains under investigation, MAPK6 plays a part in cell migration and has been implicated in the invasiveness of certain cancers. It is currently considered a promising, but understudied, therapeutic target for inhibitor-based cancer therapy.

Other names

MAPK6ERK3HsT17250PRKM6p97MAPKmitogen-activated protein kinase 6

Kinase inhibition (type I kinase inhibitors identified, block the ATP binding pocket of MAPK6/ERK3); Inhibitor action blocks protein phosphorylation and downstream signaling mediated by MAPK6