Mitogen-activated protein kinase 6 pseudogene 1 (MAPK6P1)

Mitogen-activated protein kinase 6 pseudogene 1 (MAPK6P1, Erk3ps1) is a noncoding pseudogene related to the MAPK6 (ERK3) gene. Pseudogenes are genomic DNA sequences similar to normal genes but generally nonfunctional; they do not produce active protein, often due to key disabling mutations or transcriptional silencing. Some pseudogenes can be transcribed into RNA and may act as competing endogenous RNAs (ceRNAs) or microRNA decoys, influencing the stability and translation of their parent gene's transcript, as has been shown for other pseudogenes such as PTENP1 or KRAS1P in cancer[1][2]. However, there is no literature evidence that MAPK6P1 itself is functionally active as a disease regulator, biomarker, or drug target. Is there something wrong with this target? Yes; MAPK6P1/Erk3ps1 is not a therapeutic target. It is a pseudogene, and does not encode a protein product or have any established druggability or direct disease-relevance according to current literature and gene databases. If a therapeutic target is intended, the parental gene (e.g., MAPK6/ERK3) should be specified instead. Note: - If you require information about the functional protein MAPK6 (ERK3), that is a distinct entity and is a member of the MAP kinase family. - Many pseudogenes do not have experimentally confirmed biological functions and are generally not included in drug target databases.

Other names

Erk3ps1MAPK6P1Mitogen-activated protein kinase 6 pseudogene 1

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