Mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2 (MAPK8IP1P2)

Mitogen-activated protein kinase 8 interacting protein 1 pseudogene 2 (MAPK8IP1P2) is a pseudogene that does not encode a protein but is transcribed as a long non-coding RNA (lncRNA). Recent studies show that lncRNA-MAPK8IP1P2 is downregulated in thyroid cancer tissues with lymphatic metastasis. Functional studies indicate that upregulation of MAPK8IP1P2 inhibits, while silencing promotes, lymphatic metastasis and anoikis resistance in thyroid cancer cells. Mechanistically, MAPK8IP1P2 activates Hippo signaling by sponging miR-146b-3p, thus relieving repression on NF2, RASSF1, and RASSF5 expression. This pathway suppresses tumor metastasis, highlighting potential relevance as a biomarker for lymphatic metastatic risk in thyroid cancer, but not as a direct molecular drug target. Key points: MAPK8IP1P2 is a lncRNA pseudogene, not a protein or classic druggable target. Not a receptor, enzyme, transporter, or signaling protein. Has emerging significance as a biomarker, not as a direct therapeutic target. Main function relates to competitive endogenous RNA activity in cancer cell biology.

Other names

MAPK8IP1P2lncRNA-MAPK8IP1P2

Acts as a molecular “sponge” for miR-146b-3p, modulating downstream gene expression relevant to tumor metastasis