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Target intelligence / Profile preview
Mitogen-activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2)
- Target
- MAPKAPK2
- Molecular classification
- Enzyme, Serine/threonine kinase, Protein kinase
01
Overview
Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2), also known as MK2, is a serine/threonine-protein kinase that plays a central role in cellular responses to stress and inflammation. It is activated by p38 MAP kinase and regulates cytokine production, cell migration, and DNA damage repair. It has been implicated in cancer and inflammatory diseases and is a potential therapeutic target. Major substrates include HSP27, Cdc25B/C, and RNA-binding proteins ZFP36/tristetraprolin and ELAVL1/HuR.
- Other names
- MK2
02
Mechanism of action
Kinase inhibition
03
Biological functions
Stress responseInflammatory signalingDNA damage responseCell migrationCytoskeletal organizationCytokine regulationCell cycle progressionImmune regulationPost-transcriptional gene expression
04
Disease associations
CancerInflammatory diseasesArthritisFibrosisARDSAutoimmunity
05
Safety considerations
Potential for off-target effectsDevelopment of resistanceToxicity related to immune modulation
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