Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5)
- Target
- MAPKAPK5
- Molecular classification
- Serine/threonine-protein kinase, Enzyme
01
Overview
MAPKAPK5 is a serine/threonine-protein kinase that functions as a tumor suppressor and is involved in cellular stress responses. It is activated by phosphorylation through upstream MAPKs. Upon activation, it translocates from the nucleus to the cytoplasm and phosphorylates several substrates, notably heat shock protein HSP27 and FOXO3. Diseases associated with altered function or expression of MAPKAPK5 include neurocardiofaciodigital syndrome, pulmonary immaturity, and possibly Alzheimer's disease. There are also implications for cancer progression and hepatocellular carcinoma.
- Other names
- PRAKp38-regulated/activated protein kinase
02
Mechanism of action
Phosphorylation of downstream targets, including HSP27 and FOXO3.
03
Biological functions
Tumor suppressionResponse to cellular stressRegulation of cell motilityGene expression regulationTP53 activity modulationCell cycle controlMetabolism regulationDifferentiation processes
04
Disease associations
Neurocardiofaciodigital syndromePulmonary immaturityAlzheimer's diseaseCancer progressionHepatocellular carcinoma
Beyond the preview
Go deeper on Mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5).