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Target intelligence / Profile preview
Mitogen-activated protein kinase-activated protein kinase II (MK2)
- Target
- MK2
- Molecular classification
- Serine/threonine-protein kinase, Enzyme
01
Overview
Mitogen-activated protein kinase-activated protein kinase II (MK2) is a serine/threonine protein kinase that plays a central role in cellular stress and inflammatory responses. It is directly regulated by p38 mitogen-activated protein kinases (MAPKs) and phosphorylates various substrates involved in cytokine production, mRNA stability, actin cytoskeleton remodeling, and cell cycle regulation. MK2 is considered an attractive therapeutic target for inflammatory diseases, fibrosis, and cancer metastasis.
- Other names
- MAPKAPK2
02
Mechanism of action
Inhibition of MK2 phosphorylation of downstream targets
03
Biological functions
Regulation of cytokine productionControl of mRNA stability and translationActin cytoskeleton remodelingCellular response to stressInflammatory responseCell cycle regulation
04
Disease associations
Inflammatory diseasesFibrosis-related disordersCancer metastasis
05
Safety considerations
Potential side effects associated with broader p38 pathway blockade (avoided by targeting MK2)
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