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Target intelligence / Profile preview
Mitogen-activated protein kinase B-Raf (BRAF)
- Target
- BRAF
- Molecular classification
- Enzyme, Protein Kinase, MAPKKK
01
Overview
Mitogen-activated protein kinase B-Raf (BRAF) is a serine/threonine-protein kinase that plays a central role in the RAS/RAF/MEK/ERK signaling pathway. This pathway transmits signals from cell surface receptors to the nucleus, regulating key cellular processes such as proliferation, differentiation, migration, and apoptosis. Mutations in BRAF, particularly V600E, are implicated in several cancers, making it an important therapeutic target. Several small-molecule inhibitors have been developed targeting mutant forms of B-Raf.
- Other names
- Serine/threonine-protein kinase B-Raf
02
Mechanism of action
Inhibition of BRAF kinase activity
03
Biological functions
Signal transductionCell proliferationCell differentiationCell migrationApoptosisRegulation of gene expression
04
Disease associations
CancerMelanomaColorectal cancerThyroid cancerLung cancerMultiple myeloma
05
Safety considerations
Resistance mechanisms due to dimerization or alternative splicing variants of RAF proteinsParadoxical activation in some cases where only one RAF isoform is inhibited
06
Interacting drugs
Vemurafenib
2 more in the full profile.
07
Biomarkers
BRAF V600E mutation
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