Mitogen-activated protein kinase-binding protein 1 (MAPKBP1)

Mitogen-activated protein kinase-binding protein 1 (MAPKBP1) is a scaffold/adaptor protein that connects and spatially organizes MAPK/JNK kinase and NOD2 signaling pathways, impacting immune responses and cellular stress signaling. It binds WDR62 via a dimerization domain to modulate the JNK cascade and associates with NOD2 to negatively regulate immune responses. Dysfunction or improper localization caused by MAPKBP1 mutations leads to nephronophthisis 20, a rare autosomal-recessive kidney disease. While no therapies currently target MAPKBP1 directly, its central role in JNK/NOD2 signaling makes it a candidate for research in targeted immunity, inflammation, and cell signaling[1][2][3][5]. Key Points: - MAPKBP1 is best classified as a scaffold/adaptor protein rather than a classical receptor, enzyme, or ion channel. - Primary established disease link is to nephronophthisis 20, with no current drug-targeting or biomarker status in clinical medicine. - No incorrect assignment, essential aliases provided, and no safety risks described for clinical application due to lack of drug targeting. - Potential for future research as a therapeutic target in immune-modulated diseases and signaling disorders.

Other names

JNKBP1KIAA0596JNK-binding protein 1NPHP20MAPKBP1JNKBP-1Mitogen-activated protein kinase binding protein 1

No approved drugs, therefore mechanism not established; theoretically drugs might modulate JNK or NOD2 pathways by affecting MAPKBP1 function as a scaffold/adaptor