Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitogen-activated protein kinase C-Raf (RAF1)
- Target
- RAF1
- Molecular classification
- Serine/threonine-protein kinase, MAP3 kinase, Enzyme
01
Overview
Mitogen-activated protein kinase C-Raf (RAF1) is a serine/threonine-protein kinase that serves as a critical regulatory link between membrane-associated Ras GTPases and the MAPK/ERK signaling cascade. It is a principal component of the mitogen-activated protein kinase (MAPK) pathway, specifically acting as a MAP3 kinase that initiates the downstream phosphorylation cascade leading to cell proliferation, differentiation, survival, and gene expression. Aberrant RAF1 activation is implicated in various cancers and developmental syndromes, making it an important therapeutic target.
- Other names
- c-RafRAFProto-oncogene c-RAFMAPK/ERK pathway kinase
02
Mechanism of action
Inhibition of RAF kinase activity, blocking downstream MAPK/ERK signaling
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalGene expression regulationMAPK/ERK pathway regulation
04
Disease associations
CancerNoonan SyndromeLEOPARD SyndromeDevelopmental disorders
05
Safety considerations
Potential for off-target effects due to kinase family similarityDevelopment of resistance through mutations in RAF or downstream effectorsParadoxical activation of the MAPK pathway in some contexts
06
Interacting drugs
Sorafenib
Beyond the preview
Go deeper on Mitogen-activated protein kinase C-Raf (RAF1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitogen-activated protein kinase C-Raf (RAF1).