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Target intelligence / Profile preview
Mitogen-Activated Protein Kinase Interacting Kinase (MNK)
- Target
- MNK
- Molecular classification
- Serine/threonine-protein kinase, MAP kinase-interacting kinase, Enzyme
01
Overview
Mitogen-activated protein kinase interacting kinases (MNKs) are serine/threonine kinases that are downstream effectors of the MAPK signaling pathways. The two main isoforms, MNK1 and MNK2, regulate mRNA translation by phosphorylating eIF4E. This regulation influences cell proliferation, survival, differentiation, stress responses, inflammation, and tumorigenesis, making MNKs potential therapeutic targets, especially in cancer.
- Other names
- MNKIMNKKMNK1MNK2
02
Mechanism of action
Inhibition of MNK kinase activity, thereby reducing eIF4E phosphorylation and cap-dependent translation.
03
Biological functions
Regulation of mRNA translationCell proliferationStress responseInflammationSignal transduction
04
Disease associations
CancerInflammationCardiac remodeling
05
Safety considerations
Potential for broad effects on protein translationNeed for selective inhibitors to avoid off-target effects
06
Biomarkers
eIF4E phosphorylation levelsMNK expression levels
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