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Target intelligence / Profile preview
Mitogen-activated protein kinase-interacting kinase 2 (MK2)
- Target
- MK2
- Molecular classification
- Enzyme, Serine/threonine protein kinase
01
Overview
Mitogen-activated protein kinase-interacting kinase 2 (MK2) is a serine/threonine protein kinase activated by p38 MAPK. It plays a crucial role in cellular responses to stress and inflammation, cell division, apoptosis, and DNA damage repair. As a downstream effector of p38 MAPK, it regulates inflammatory cytokine mRNA stability and translation, cell cycle checkpoints, apoptosis, and cell motility. MK2 is considered a therapeutic target for inflammatory diseases and cancer, particularly in tumors with mutated p53.
- Other names
- MAPKAPK2Mitogen-activated protein kinase-activated protein kinase-2
02
Mechanism of action
Inhibition of MK2 kinase activity
03
Biological functions
Inflammation controlCell cycle checkpointApoptosis regulationCell motilityDNA damage responsemRNA stability regulationTranslation regulation
04
Disease associations
Inflammatory diseasesCancerFibrosisArthritis
05
Safety considerations
Potential for off-target effects due to kinase family similarities.Development of resistance to MK2 inhibitors.
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