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Target intelligence / Profile preview
Mitogen-Activated Protein Kinase Kinase 1 and 2 (MEK1/2)
- Target
- MEK1/2
- Molecular classification
- Enzyme, Protein Kinase, MAP kinase kinase (MAPKK), Dual-specificity protein kinase
01
Overview
MEK1 and MEK2 are closely related dual-specificity protein kinases that play a central role in the RAS-RAF-MEK-ERK signal transduction cascade. This pathway is crucial for regulating diverse cellular processes such as apoptosis, cell cycle progression, migration, differentiation, metabolism, and proliferation. MEK1/2 phosphorylate and activate ERKs (extracellular signal-regulated kinases), specifically ERK1/ERK2. The pathway is frequently hyperactivated due to upstream mutations in RAS or BRAF genes—a common event across many human cancers—making MEKs key therapeutic targets.
- Other names
- MAP kinase kinase (MAPKK)Dual-specificity protein kinaseMAP/ERK KinaseMKK
02
Mechanism of action
Small-molecule inhibition of MEK1/2 kinase activity.
03
Biological functions
Signal transductionApoptosisCell cycle progressionCell migrationCell differentiationMetabolismCell proliferationERK activation
04
Disease associations
Cancer
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