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Target intelligence / Profile preview
Mitogen-Activated Protein Kinase Kinase 2 (MEK2)
- Target
- MEK2
- Molecular classification
- Enzyme, Protein Kinase, MAP Kinase Kinase
01
Overview
MEK2 is a dual-specificity protein kinase that plays a central role in the RAS/RAF/MEK/ERK signal transduction cascade. It phosphorylates and activates ERK1 and ERK2, which are critical for transmitting mitogenic signals. MEK2-mediated signaling regulates cell proliferation, differentiation, apoptosis, and cell migration. Dysregulation of MEK2 is implicated in cancer and developmental disorders like Cardiofaciocutaneous syndrome.
- Other names
- MKK2MAPKK2PRKMK2CFC4Dual specificity mitogen-activated protein kinase kinase 2ERKK activator kinase 2
02
Mechanism of action
Inhibition of MEK2 kinase activity
03
Biological functions
Signal transductionCell proliferationCell differentiationApoptosisCell migration
04
Disease associations
CancerCardiofaciocutaneous syndrome
05
Safety considerations
Dysregulation can contribute to oncogenesisToxicity issues associated with MEK inhibitors
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