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Mitogen-activated protein kinase kinase 3 (MAP2K3)

Target: MAP2K3
Molecular classification: Enzyme, Protein kinase, Mitogen-activated protein kinase kinase (MAPKK/MEK), Signal transduction molecule

Overview

Mitogen-activated protein kinase kinase 3 (MAP2K3, also known as MEK3) is a dual-specificity protein kinase that phosphorylates and activates p38 MAP kinases in response to cellular stress and pro-inflammatory cytokines. MAP2K3 acts as a key intermediary in the MAPK signaling cascade, playing a critical role in modulating inflammation, apoptosis, and cell differentiation.

Other names: MEK3MAP2K3Mitogen-activated protein kinase kinase 3PRKMK3MKK3

Mechanism of action

Inhibition of MAP2K3 prevents activation of downstream p38 MAP kinases, affecting cellular stress and inflammatory responses.

Biological functions

Signal transductionStress responseInflammationCell proliferationApoptosis

Disease associations

CancerInflammationAutoimmune diseaseNeurodegenerative disease

Safety considerations

Potential broad effects on immune response and cell survival.Off-target or systemic inhibition may lead to unwanted immunosuppression or impaired stress adaptation.

Interacting drugs

There are currently no approved drugs that clinically target MAP2K3 selectively, but experimental inhibitors and tool compounds (e.g., BIX02188, BIX02189) exist.

Biomarkers

Phosphorylation status of MAP2K3 (or its downstream effectors, such as p38 MAPK) may serve as a biomarker for pathway activation in research contexts.

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