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Target intelligence / Profile preview
Mitogen-activated protein kinase kinase 4 (MKK4)
- Target
- MKK4
- Molecular classification
- Serine/threonine-specific protein kinase, Dual-specificity kinase, Enzyme
01
Overview
MKK4 is a dual-specificity protein kinase that phosphorylates and activates JNKs and p38 MAPKs in response to cellular stresses and proinflammatory cytokines. It plays a critical role in stress response, immune function, and embryonic development. Its role in cancer is complex, with evidence suggesting both tumor suppressor and pro-oncogenic functions.
- Other names
- MAP2K4SEK1JNKK1
02
Mechanism of action
Phosphorylates and activates JNKs and p38 MAPKs.
03
Biological functions
Signal transductionStress responseImmune regulationCell proliferationApoptosisDifferentiation
04
Disease associations
CancerInflammationImmune disordersDevelopmental disorders
05
Safety considerations
Context-dependent tumor suppressor/pro-oncogenic roles complicate therapeutic targeting.
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