Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), commonly referred to as NF-κB-inducing kinase. (NIK)

NF-κB-inducing kinase (NIK) is a serine/threonine kinase encoded by the MAP3K14 gene that regulates the activation of the NF-κB transcription factor family, particularly through the non-canonical pathway. It phosphorylates p100, leading to its conversion into active p52 and subsequent nuclear translocation of NF-κB heterodimers, modulating gene expression critical for immune responses, cell survival, inflammation, and apoptosis. Dysregulation of NIK activity is implicated in autoimmunity and cancer, making it a therapeutic target of scientific and clinical interest. Its kinase domain is constitutively active in certain contexts, independent of phosphorylation, and its regulation maintains a balance between pro- and anti-inflammatory signaling events.

Other names

NF-κB-inducing kinaseNIKMAP3K14

Drugs targeting NIK typically act as inhibitors of its kinase activity, blocking non-canonical NF-κB activation and downstream gene transcription relevant to cell survival, proliferation, inflammation, and apoptosis resistance.