Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitogen-Activated Protein Kinase Kinase Kinase 19 (MAP3K19)
- Target
- MAP3K19
- Molecular classification
- Enzyme, Protein Kinase, Serine/Threonine Kinase, MAP3K
01
Overview
Mitogen‐activated protein kinase kinase kinase 19 (MAP3K19) is a serine/threonine protein kinase that functions as an upstream regulator in the mitogen-activated protein kinase (MAPK) signaling cascade. It activates both ERK and JNK pathways and plays a role in cell survival, especially under oncogenic stress conditions. It is overexpressed in lungs from patients with COPD and displays varying expression patterns in different cancers.
- Other names
- YSK4RCKRegulated-in-COPD KinaseSPS1/STE20-related protein kinase YSK4
02
Mechanism of action
Kinase inhibition
03
Biological functions
Signal transductionCell proliferationCell survivalRegulation of MAPK cascadePhosphorylation
04
Disease associations
CancerChronic Obstructive Pulmonary Disease (COPD)Breast Diseases
05
Safety considerations
Context-dependent roles in different tumor typesPotential for off-target effects due to kinase activity
Beyond the preview
Go deeper on Mitogen-Activated Protein Kinase Kinase Kinase 19 (MAP3K19).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitogen-Activated Protein Kinase Kinase Kinase 19 (MAP3K19).