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Target intelligence / Profile preview
Mitogen-activated protein kinase kinase kinase 2 (MEKK2)
- Target
- MEKK2
- Molecular classification
- Enzyme, Serine/threonine-protein Kinase
01
Overview
Mitogen-activated protein kinase kinase kinase 2 (MAP3K2), also known as MEKK2, is a serine/threonine protein kinase that plays a central role in cellular signal transduction pathways, particularly those regulating cell proliferation, differentiation, survival, and stress responses. It activates the JNK, ERK5, and NF-kappa B pathways and is implicated in multiple diseases including cancers, inflammatory disorders, fibrosis, arthritis, and immune system dysfunctions.
- Other names
- MAP3K2MEKK2B
02
Mechanism of action
Not applicable
03
Biological functions
Signal transductionCell proliferationApoptosisInflammationGene expression regulationCell growthStress responseCytoskeletal rearrangement
04
Disease associations
CancerInflammatory disordersFibrosisArthritisImmune system dysfunctions
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