Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) is a serine/threonine protein kinase that plays a central role in cellular signal transduction, particularly in response to external stimuli. It acts as an upstream activator of several key pathways, including the SAPK/JNK and ERK1/2 pathways, and mediates activation of transcriptional regulators such as NF-kappa-B, AP1, and DDIT3. MAP3K3 is involved in regulating cell fate decisions such as proliferation, differentiation, and survival/apoptosis. Overexpression or dysregulation of MAP3K3 can promote tumor growth.

Other names

MAPKKK3MEKK3

MAP3K3 phosphorylates and activates downstream kinases in the SAPK/JNK and ERK1/2 pathways, leading to activation of transcriptional regulators such as NF-kappa-B, AP1, and DDIT3.