Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8)
- Target
- MAP3K8
- Molecular classification
- Serine/threonine protein kinase, STE-unique family, MAP3K
01
Overview
MAP3K8 encodes a serine/threonine-specific protein kinase involved in the regulation of inflammatory and immune responses. It activates ERK1/2, p38 MAP kinases, and IκB kinases, leading to NF-κB activation and the production of pro-inflammatory cytokines. It has been implicated in cancer development and chronic inflammatory diseases. Pharmacological inhibition is being explored for treatment of chronic inflammation.
- Other names
- TPL2CotCOTMEKK8ESTFc-COTAURA2
02
Mechanism of action
Inhibition of MAP3K8 activity
03
Biological functions
Activation of ERK1/2 and p38 MAP kinasesActivation of IκB kinases leading to nuclear translocation of NF-κBPromotion of pro-inflammatory cytokines such as TNF-alpha and IL-2 during T lymphocyte activationRegulation of local inflammationInflammatory signalingImmune cell activationCell proliferation
04
Disease associations
CancerChronic inflammatory diseasesAutoimmune disorders
05
Safety considerations
Potential for immunosuppressionContext-dependent oncogenic or tumor-suppressive roles
Beyond the preview
Go deeper on Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8).