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Target intelligence / Profile preview
Mitogen-activated protein kinase kinase kinase kinase (MAP4K)
- Target
- MAP4K
- Molecular classification
- Serine/threonine-protein kinase, Enzyme
01
Overview
Mitogen-activated protein kinase kinase kinases (MAP4Ks) are a family of serine/threonine protein kinases that function as upstream regulators in MAPK signaling cascades. They play critical roles in cell apoptosis, survival, autophagy, cell migration, immune cell signaling, and organ size control, making them potential therapeutic targets for cancer, autoimmune diseases, and inflammation.
- Other names
- HPK1GCKGLKHGKKHSMINKMAP4K1MAP4K2MAP4K3MAP4K4MAP4K5MAP4K6
02
Mechanism of action
Kinase inhibition
03
Biological functions
Apoptosis regulationAutophagyCell migrationImmune responseCell survivalSignal transductionOrgan size controlTumor suppression
04
Disease associations
CancerAutoimmune diseasesInflammationImmunodeficiency
05
Safety considerations
Potential for broad pathway dysregulation due to upstream kinase targetingImmune system modulation
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