Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) is a serine/threonine protein kinase in the MAP kinase kinase kinase kinase family, encoded by the MAP4K3 gene in humans[1][2][3][6]. It plays pivotal roles in signal transduction, especially in cellular responses to environmental stress, regulation of autophagy, and as an upstream activator of the c-Jun N-terminal kinase pathway[1][2][3][5][6]. MAP4K3 is also an activator of the Hippo signaling pathway, which restricts cell proliferation and promotes apoptosis, contributing to tumor suppression and organ size control[1][3][6]. Alternative splicing results in multiple isoforms[2]. Mutations or dysregulation of MAP4K3 have implications in cancer and stress recovery, among other physiological processes[1][5][6]. Fostamatinib is reported as an inhibitor, though specific clinical targeting remains to be more fully characterized[3].

Other names

MAP4K3GLKMEKKK3MEKKK 3MAPKKKK3RAB8IPL1Germinal center kinase-related protein kinaseMAPK/ERK kinase kinase kinase 3MEK kinase kinase 3Germinal center kinase-like kinase

Kinase inhibition (as with fostamatinib: blocks serine/threonine kinase activity)[3]