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Target intelligence / Profile preview
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)
- Target
- MAP4K4
- Molecular classification
- Enzyme, Serine/threonine protein kinase, Ste20 family kinase
01
Overview
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) is a serine/threonine protein kinase that belongs to the Ste20 family of kinases. It plays a key role in several cellular processes, including cell migration, proliferation, adhesion, cytoskeleton dynamics, and signal transduction within the MAPK signaling pathway. MAP4K4 acts as an upstream regulator within the MAPK signaling cascade, regulating cytoskeleton dynamics, cell motility, and insulin sensitivity. Dysregulation or mutation of MAP4K4 has been associated with various pathologies, including cancer and metabolic diseases.
02
Mechanism of action
Kinase inhibitor
03
Biological functions
Cell migrationCell proliferationCell adhesionCytoskeleton dynamicsSignal transductionRegulation of insulin-responsive glucose transportRegulation of adipogenesisRegulation of lipogenesisStress response
04
Disease associations
CancerMetabolic diseaseDiabetes
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