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Target intelligence / Profile preview
Mitogen-Activated Protein Kinase p38 Alpha (p38α)
- Target
- p38α
- Molecular classification
- Enzyme, Serine/threonine kinase, MAP kinase
01
Overview
Mitogen-activated protein kinase p38 alpha (p38α or MAPK14) is a serine/threonine kinase belonging to the MAP kinase family. It plays a central role in cellular responses to stress, inflammation, cell differentiation, apoptosis, and immune responses. It is activated by dual phosphorylation by MKK3/MKK4 and regulates numerous transcription factors, influencing gene expression programs. Chronic activation is associated with inflammatory diseases, neurodegeneration, cardiac issues, and muscle diseases. While p38α inhibition has been explored for treating inflammatory and cardiac disorders, clinical outcomes have been mixed.
- Other names
- MAPK14Cytokine suppressive drug binding proteinCSBPReactivating kinaseRK
02
Mechanism of action
Kinase inhibition
03
Biological functions
Stress responseInflammationImmune responseCell differentiationApoptosisTranscription regulationCell cycle
04
Disease associations
Inflammatory diseasesRheumatoid arthritisNeurodegenerationCNS autoimmunityCardiac hypertrophyCardiac remodelingIschemia-reperfusion injuryMuscle diseaseMyogenesis defects
05
Safety considerations
Mixed clinical results due to complex roles across tissuesPotential for off-target effects
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