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Target intelligence / Profile preview
Mitomycin C
- Molecular classification
- Antineoplastic antibiotic, Alkylating agent
01
Overview
Mitomycin C is a natural product-derived antineoplastic antibiotic and chemotherapeutic agent that functions primarily by forming covalent interstrand crosslinks in DNA after enzymatic reduction inside cells. This action blocks both replication and transcription processes essential for cell survival—making it highly effective against rapidly dividing tumor cells but also responsible for significant side effects due to lack of selectivity between normal proliferative tissues and tumors.
- Other names
- MitosolMutamycinJelmytoUGN-101
02
Mechanism of action
DNA crosslinking → inhibits replication/transcription → apoptosis
03
Biological functions
DNA crosslinkingInhibition of DNA replicationInhibition of transcriptionApoptosis inductionAntibacterial activity
04
Disease associations
Cancer
05
Safety considerations
MyelosuppressionNephrotoxicityPulmonary toxicityDelayed secondary malignanciesCytotoxicity
06
Interacting drugs
None
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