Target intelligence / Profile preview

Mitosis Inhibitor

Molecular classification: Other

Overview

A mitosis inhibitor is a molecule or drug that disrupts the process of mitosis—cell division—by interfering with the assembly and disassembly of microtubules. These agents are primarily used in cancer therapy due to their ability to selectively target rapidly dividing cells.

Other names: Mitotic InhibitorAntimitotic AgentMicrotubule InhibitorTubulin Inhibitor

Mechanism of action

Disrupts microtubule dynamics by interfering with the assembly and disassembly of tubulin, leading to cell cycle arrest at metaphase and induction of apoptosis. Some inhibitors also target key regulatory kinases involved in mitosis, such as aurora kinases and CDK1.

Biological functions

Cell cycleApoptosisCell deathCell proliferation

Disease associations

CancerGoutFungal infection

Safety considerations

Toxicity toward normal dividing cellsMitotic slippageDevelopment of drug resistance

Interacting drugs

Paclitaxel

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