Mitosis machinery protein

"Mitosis machinery proteins" is a broad term referring to the collection of **proteins and multi-protein complexes that orchestrate the process of mitosis**, including but not limited to microtubules (composed of α/β-tubulin), motor proteins such as kinesins and dynein, regulatory enzymes like cyclin-dependent kinases (CDKs), Polo-like kinases (PLKs), Aurora kinases, spindle assembly checkpoint components like Mad/Bub family members, centrioles/centrosomes structural proteins such as TRIM37-regulated factors and others. These molecules collectively ensure accurate chromosome segregation into daughter cells during cell division. Disruption of their function can lead to chromosomal instability—a hallmark of many cancers—and thus they are considered important targets for anticancer therapy. However, "mitosis machinery protein" is not a single molecular entity but rather an umbrella term encompassing hundreds of distinct gene products with diverse structures and functions[2][6][4]. Drugs that target this system include classic antimitotics like taxanes and vinca alkaloids which interfere with microtubule dynamics—key elements in the mitotic spindle—and newer agents targeting specific regulatory enzymes involved in mitosis progression[1][5]. **Note:** There is something incorrect about using "Mitosis machinery proteins" as a drug target name—it refers to an entire class/family rather than a unique molecular entity suitable for structured annotation. For structured data purposes it would be necessary to specify individual targets within this group—such as "Aurora kinase A," "Polo-like kinase 1," or "Kinesin family member 11"—rather than use this collective label[2].

Other names

Mitotic machinery proteinsCell division machinery proteinsMitotic apparatus components

Drugs targeting mitosis machinery proteins generally act by inhibiting microtubule polymerization or depolymerization or by inhibiting key mitotic kinases. This disrupts spindle formation and chromosome segregation during cell division[5][1].