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Mitotic activity in keratinocytes refers to the process by which these epidermal cells undergo cell division (mitosis) to maintain skin homeostasis, enable regeneration, and support wound healing. It is a tightly regulated process involving various molecular checkpoints and division orientations to ensure balanced self-renewal versus commitment toward terminally differentiated states. Dysregulation of this process is implicated in diseases like psoriasis and can potentially lead to tumorigenesis if left unchecked.
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