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Target intelligence / Profile preview
Mitotic kinesin Eg5 (Eg5)
- Target
- Eg5
- Molecular classification
- Kinesin superfamily, Kinesin-5 family, Mitotic motor
01
Overview
Mitotic kinesin Eg5, also known as Kinesin-5, KSP, or KIF11, is a member of the kinesin superfamily involved in spindle formation and maintenance during mitosis. As a homotetrameric bipolar motor protein, it crosslinks and slides apart anti-parallel microtubules, driving centrosome separation and maintaining spindle bipolarity. Eg5 moves toward the plus ends of microtubules using ATP hydrolysis. It is a validated target for antimitotic cancer therapies, and small-molecule inhibitors block its function, leading to mitotic arrest. Outside of cell division, Eg5 is involved in axonal growth regulation and may serve as a mobile link between ribosomes and microtubules.
- Other names
- Kinesin-5Kinesin spindle protein (KSP)KIF11
02
Mechanism of action
Inhibition of Eg5 ATPase activity, leading to mitotic arrest and apoptosis
03
Biological functions
Spindle formationSpindle maintenanceCentrosome separationSpindle elongationMicrotubule organizationChromosome segregationAxonal growth regulationMicrotubule-based transport
04
Disease associations
CancerGenomic instability
05
Safety considerations
Potential for off-target effects, although generally considered to have a lower toxicity profile than traditional chemotherapies due to selective expression in dividing cells.
06
Interacting drugs
Eg5 inhibitors
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