Mitotic kinesin-like protein 1 (MKLP1)

Mitotic kinesin-like protein 1 (MKLP1, also known as KIF23 or CHO1) is a plus end–directed microtubule-dependent motor protein and a key component of the centralspindlin complex, required for cytokinesis in animal cells[4][7][8]. MKLP1 cross-bridges antiparallel microtubules of the central spindle during anaphase and becomes concentrated in the midbody during cytokinesis, where it drives the formation of the cleavage furrow and completion of cell division[7][8][9]. In neurons, MKLP1 contributes to the regulation of microtubule transport and dendrite formation[7]. Dysfunction or overexpression of MKLP1 has been linked to cancer and possibly hereditary cell division disorders[8][9]. As it is essential in rapidly dividing cells, MKLP1 is regarded as a potential anti-cancer drug target[8].

Other names

KIF23CHO1Kinesin family member 23Mitotic kinesin-like protein 1Kinesin-6ZEN-4Pavarotti

Inhibition of motor activity: Drugs targeting MKLP1/KIF23 would be expected to block its ATPase/microtubule-interacting functions, leading to failed cytokinesis and cancer cell death. Disruption of spindle assembly and furrow ingression