Target intelligence / Profile preview

Mitotic progression

Molecular classification
Other
01

Overview

Mitotic progression refers to the sequence of events by which a eukaryotic cell passes through the stages of mitosis—prophase, prometaphase, metaphase, anaphase, and telophase—resulting in the equal segregation of duplicated chromosomes into two genetically identical daughter nuclei[1][2][3]. This process is essential for growth, tissue repair, and maintenance in multicellular organisms. Dysregulation or errors in mitotic progression are associated with diseases such as cancer due to uncontrolled cell proliferation[3]. However, "mitotic progression" itself is not a specific molecule or receptor but rather describes a cellular process involving numerous proteins and regulatory pathways. Notes on correctness ("is_incorrect"): The term "mitotic progression" does not refer to a single molecular target such as an enzyme or receptor; instead it describes a biological process. Therefore it cannot be considered a canonical therapeutic target on its own[1][2][3]. If you are seeking information about druggable targets involved in this process (such as Aurora kinases or Polo-like kinases), those should be specified individually.

Other names
Mitotic phaseM phaseMitosis progressionProgression through mitosis
02

Biological functions

Cell cycleCell divisionChromosome segregationCell proliferation
03

Disease associations

Cancer (as dysregulation of mitotic progression is a hallmark of many cancers)Other (tissue regeneration disorders)
04

Safety considerations

Targeting general mitotic progression can lead to toxicity in normal proliferating cells (e.g., bone marrow suppression, gastrointestinal toxicity)

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