Mitotic spindle assembly checkpoint protein MAD1 (MAD1)

Mitotic spindle assembly checkpoint protein MAD1 (commonly called MAD1, encoded by MAD1L1) is a highly conserved cell cycle protein essential for the mitotic spindle assembly checkpoint. MAD1 acts at unattached kinetochores, recruiting MAD2 and facilitating assembly of the mitotic checkpoint complex (MCC), which delays anaphase onset until all chromosomes achieve proper spindle attachment. This prevents aneuploidy and genomic instability. MAD1 functions as a homodimer and interacts physically with MAD2L1 and other spindle checkpoint proteins. Mutations or altered regulation of MAD1 have been implicated in multiple cancers (due to loss of checkpoint control and induction of aneuploidy) and some psychiatric and neurodevelopmental disorders. While MAD1 is a pivotal node in mitotic control and a potential biomarker, it is not currently a direct therapeutic target for any drug, and modulation of its function carries significant safety concerns due to its role in chromosome segregation fidelity[1][2][3][4][5][7].

Other names

Mitotic arrest deficient 1 like 1MAD1L1MAD1PIG9TP53I9TXBP181

Not applicable (No established drugs directly target MAD1; its pathway can be indirectly affected by microtubule inhibitors and agents affecting mitotic checkpoint regulation)