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Target intelligence / Profile preview
Mitotic spindle positioning protein (MISP)
- Target
- MISP
- Molecular classification
- Other (Actin-bundling protein, cytoskeletal protein)
01
Overview
Mitotic spindle positioning protein (MISP) is an actin-bundling and focal adhesion-associated protein that plays a critical role in proper mitotic spindle positioning within cells. It operates at the interface of the actin cytoskeleton and microtubule dynamics during cell division, localizing to actin-rich structures and retraction fibers, and interacting with spindle positioning machinery such as dynactin and EB1 in a PLK1-dependent manner. MISP is phosphorylated by CDK1 during mitosis, and its depletion leads to mitotic arrest, reduced tension at kinetochores, chromosome misalignment, and increased spindle multipolarity, especially in cancer cells with extra centrosomes. It is essential for directed cell migration, spindle orientation, and may be required for proper Golgi stacking. Mutations or loss of MISP disrupt critical cytoskeletal interactions and can result in defective cell division and tumorigenesis
- Other names
- Mitotic interactor and substrate of PLK1C19orf21CapriceMISP1Mitotic spindle positioning proteinDKFZp686H18209
02
Biological functions
Mitotic spindle orientationmitotic progressioncell morphology determinationactin cytoskeleton organizationcentrosome clusteringfocal adhesioncell migrationGolgi stacking
03
Disease associations
Cancer (chromosome misalignment, spindle multipolarity)Anorectal stricture
04
Safety considerations
Mitotic arrest and chromosomal missegregation may occur with reduced MISP function, potentially contributing to cancer progression via spindle defects and aneuploidy
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