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Mitotically associated long non-coding RNA (MANCR)
- Target
- MANCR
- Molecular classification
- Long non-coding RNA (lncRNA), Non-protein coding transcript, Other
01
Overview
Mitotically associated long non-coding RNA (MANCR), also known as LINC00704, is a long non-coding RNA highly expressed in certain aggressive cancers such as triple-negative breast cancer. MANCR is located on chromosome 10 (10p15.1) and does not encode a protein[3][5]. It is upregulated in cancerous tissues and regulates cell proliferation, cell cycle progression, and genomic stability. Depletion of MANCR in cancer cells leads to reduced cell proliferation, increased DNA damage, defective cytokinesis, and increased cell death. High MANCR expression is associated with worse outcomes in breast cancer patients, making it a potential therapeutic target and prognostic biomarker. MANCR is both nuclear and cytoplasmic in localization and expressed periodically during the cell cycle, peaking during mitosis[1][2][3][5].
- Other names
- CR749391LINC00704long intergenic non-protein coding RNA 704MANCR
02
Mechanism of action
Antisense oligonucleotide-mediated knockdown (experimental approach in research settings)[1]
03
Biological functions
Cell cycle regulationRegulation of cell proliferationGenomic stability maintenanceCell viabilityRegulation of mitosis
04
Disease associations
CancerBreast cancer (with specific upregulation in triple-negative and aggressive subtypes)
05
Safety considerations
Potential challenges of targeting lncRNAs include delivery methods, specificity, and off-target effects (general to lncRNA modulation, not specific established safety data for MANCR)[1]
06
Biomarkers
MANCR expression as a prognostic marker in breast cancer (associated with poor prognosis and lower survival rates in patients expressing elevated levels)[1]
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