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Target intelligence / Profile preview
Mixed Lineage Kinase
- Molecular classification
- Enzyme, Mitogen Activated Protein Kinase Kinase Kinase (MAPKKKs/MAP3Ks), MAP3K
01
Overview
Mixed lineage kinases (MLKs) are a subfamily of serine/threonine protein kinases that belong to the mitogen-activated protein kinase kinase kinase (MAP3K) family. They act as upstream activators in MAP kinase signaling pathways, specifically phosphorylating and activating MAP2Ks, which then activate downstream MAP kinases such as JNKs and p38s. MLKs play roles in regulating cell migration, invasion, cell cycle progression, apoptosis, and stress responses. They are implicated in diseases like Parkinson’s disease and Alzheimer’s disease due to their role in neuronal apoptosis via JNK pathway activation, and some members modulate tumorigenesis through effects on cell migration/invasion. Notable family members include MLK2, MLK3, and DLK.
02
Mechanism of action
Inhibition of kinase activity; modulation of T cell function
03
Biological functions
Signal transductionApoptosisCell cycleCell migrationStress responseActivation of MAP2KsRegulation of JNK and p38 pathways
04
Disease associations
Neurodegenerative diseaseParkinson's diseaseAlzheimer's diseaseCancer
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