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Mixed lineage kinase domain-like protein (MLKL)
- Target
- MLKL
- Molecular classification
- Pseudokinase
01
Overview
MLKL is a pseudokinase that functions as the terminal effector of necroptosis. Upon activation by RIPK3-mediated phosphorylation, it oligomerizes and translocates to the plasma membrane, where it disrupts membrane integrity and triggers cell death. It has been implicated in various inflammatory, ischemic, and neurodegenerative diseases, as well as pediatric inflammatory bowel disease.
- Other names
- mixed lineage kinase domain like pseudokinasehmixed lineage kinase domain-like
02
Mechanism of action
Inhibition of MLKL oligomerization and membrane translocation, leading to suppression of necroptosis.
03
Biological functions
Cell deathNecroptosis executionMembrane disruptionRegulation of extracellular vesicle generation
04
Disease associations
Inflammatory diseasesIschemic injuryNeurodegenerationPediatric inflammatory bowel disease
05
Safety considerations
Inhibition of necroptosis may impair immune responses or tissue repair mechanisms.Species-specific differences in inhibitor binding (e.g., NSA)Potential for off-target effects due to kinase-like domain
06
Interacting drugs
Necrosulfonamide (NSA)
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