Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mixed-lineage leukemia protein (MLL)
- Target
- MLL
- Molecular classification
- Histone lysine methyltransferase, Transcription factor, Epigenetic regulator
01
Overview
The mixed-lineage leukemia protein is a crucial epigenetic regulator whose disruption by chromosomal translocation underlies some of the most aggressive forms of childhood acute leukemias. Its pathogenicity stems from loss-of-function mutations combined with gain-of-function activities conferred by diverse fusion partners that hijack normal hematopoietic differentiation programs through abnormal chromatin remodeling and sustained activation of key developmental regulators like HOX genes. This makes it both a central biomarker for diagnosis/prognosis and an attractive therapeutic target in oncology research focused on epigenetic modulation.
- Other names
- MLL1KMT2A
02
Mechanism of action
Inhibition of DOT1L enzymatic activity, disruption of Menin/MLL or LEDGF/MLL interactions, interference with super elongation complex components
03
Biological functions
Regulation of developmental genesH3K4 trimethylationTranscriptional co-activationChromatin modification
04
Disease associations
Acute lymphoblastic leukemia (ALL)Acute myeloid leukemia (AML)
05
Safety considerations
Poor prognosis associated with MLL rearrangementsTherapeutic resistance
06
Biomarkers
MLL rearrangements (translocations)
Beyond the preview
Go deeper on Mixed-lineage leukemia protein (MLL).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mixed-lineage leukemia protein (MLL).