MLLT1 super elongation complex subunit (ENL)

MLLT1 super elongation complex subunit (commonly called ENL) is a key chromatin reader protein and a critical component of the Super Elongation Complex (SEC). It contains a YEATS domain that binds acetylated and crotonylated lysine residues on histones, preferentially recognizing specific modifications such as crotonylation at lysine 27 of histone H3. ENL/MLLT1 acts as a transcriptional co-regulator, facilitating the release of paused RNA polymerase II during gene transcription, especially for genes involved in cell identity and proliferation (e.g., Myc, Hox). It is critically implicated in leukemia, where chromosomal rearrangements involving MLLT1/ENL can initiate leukemogenesis. MLLT1/ENL is the subject of current research as a potential therapeutic target, particularly in acute myeloid leukemia, with development focused on small-molecule inhibitors that disrupt its chromatin reader function[1][2][3][4][6].

Other names

MLLT1ENLLTG19YEATS1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1

Disruption or inhibition of YEATS domain binding to acetylated histones; Modulation of transcription elongation through the Super Elongation Complex; Interference with chromatin-reader functionality and gene transcription in leukemia