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MmpL3 Transporter (MmpL3)
- Target
- MmpL3
- Molecular classification
- Transporter, Membrane protein, RND family transporter
01
Overview
MmpL3 is an essential inner membrane transporter in Mycobacterium tuberculosis responsible for exporting trehalose monomycolate (TMM). TMM is a precursor for mycolic acid synthesis, a crucial component of the mycobacterial cell wall. MmpL3 functions as a proton motive force-dependent antiporter, coupling inward proton movement with outward TMM transport. Inhibition of MmpL3 disrupts cell wall biosynthesis, leading to bacterial death, making it an attractive drug target for tuberculosis.
- Other names
- Mycobacterial membrane protein Large 3TMM transporter
02
Mechanism of action
Inhibition of TMM export, disruption of mycolic acid biosynthesis and cell wall integrity.
03
Biological functions
Trehalose monomycolate (TMM) transportMycolic acid biosynthesisCell wall synthesisProton motive force-dependent transport
04
Disease associations
Mycobacterium tuberculosis infectionTuberculosis pathogenesisDrug resistance in Tuberculosis
05
Safety considerations
Potential for off-target effects on other RND transportersDevelopment of resistance mechanisms
06
Interacting drugs
SQ109 analogs
2 more in the full profile.
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