MMS19 cytosolic iron-sulfur assembly component (MMS19)

MMS19 cytosolic iron-sulfur assembly component (MMS19) is a multi-domain adapter protein crucial for iron-sulfur (Fe-S) cluster assembly and delivery to apoproteins, particularly those involved in fundamental DNA metabolic processes and genomic stability. MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, where it enables the incorporation of Fe-S clusters into DNA repair and replication factors such as ERCC2/XPD, FANCJ, and RTEL1, supporting multiple DNA repair pathways including nucleotide excision repair (NER) and homologous recombination. It also participates in the MMXD complex, contributing to mitotic spindle assembly and chromosome segregation. Additionally, MMS19 acts as a transcriptional coactivator by facilitating proper Fe-S cluster incorporation into TFIIH machinery, thereby modulating RNA polymerase II transcription and the function of nuclear hormone receptors such as the estrogen receptor. Dysfunction of MMS19 has been associated with disorders of genome instability, such as Fanconi anemia and certain mitochondrial DNA diseases, and may play a role in cancer susceptibility[1][2][3].

Other names

MMS19MMS19LhMMS19MET18CIAO4MET18 homologMMS19-like proteinMET18 homolog (S. cerevisiae)homolog of yeast MMS19MMS19 nucleotide excision repair protein homolog