MOB kinase activator 3B (MOB3B)

MOB kinase activator 3B is a member of the MOB (Mps one binder) family of kinase regulators, structurally and functionally similar to yeast Mob1. It activates or modulates kinases within the Hippo signaling pathway, which is crucial for controlling organ size via regulation of cell proliferation, apoptosis, and tumor suppression. Loss or reduced expression of MOB3B has been implicated in aggressive forms of prostate cancer and may serve as a biomarker for disease risk. The protein acts as a co-activator of LATS1 kinase, a core Hippo pathway effector, and is essential for normal mitotic checkpoint regulation and possibly other cell cycle-related processes[1][2][3][4].

Other names

C9orf35MOBKL2BMOB1DMob1 homolog 2bFLJ13204Mps one binder kinase activator-like 2B

Drugs (often experimental or broad-spectrum) that modulate cellular kinases or Hippo pathway components may alter MOB3B expression, affecting cell proliferation and apoptosis[1][2].