Molybdate-anion transporter (SLC61A1)

Molybdate-anion transporter (SLC61A1, also known as MFSD5) is a multi-pass membrane protein that functions as a high-affinity transporter for molybdate ions, a biologically essential trace element involved in the function of various enzymes. It belongs to the major facilitator superfamily (MFS) of transporters and is predicted to mediate the uptake of molybdate across cellular membranes, particularly in neuronal plasma membranes[1][4][6][8]. While it is a plausible therapeutic target due to its transporter function, there are no established interacting drugs or clear roles in major human diseases. The gene is located in the plasma membrane and is considered an atypical member of the solute carrier transporter family, specifically designated SLC61A1[1][2][6][8]. The precise physiological and pathological roles remain under investigation, but associated studies suggest a potential link to extratemporal epilepsy[8]. No current therapy targets this transporter, and no safety or biomarker issues are defined.

Other names

MFSD5hsMOT2Major facilitator superfamily domain-containing protein 5SLC61A1MGC11308Molybdate transporter 2 homologmolybdate-anion transporter

Not established for drug action; mediates high-affinity intracellular uptake of molybdate ions