Target intelligence / Profile preview

Monkeypox virus antigen A35 (A35)

Target: A35
Molecular classification: Glycoprotein, Viral protein, Immunomodulator

Overview

Monkeypox virus antigen A35 (A35R) is a viral surface glycoprotein and a key immunogenic target in MPXV infection. It is highly conserved among orthopoxviruses and plays roles in both immune evasion and virulence by inhibiting the production of immunoglobulins. The protein is a strong target of neutralizing antibodies following MPXV infection, and recombinant forms are used for serodiagnostic applications and antibody discovery.

Other names: Antigen A35Protein A35A35R

Mechanism of action

Neutralization of viral entry/infection

Biological functions

ImmunomodulationImmune evasionViral virulence

Disease associations

InfectionMonkeypox

Biomarkers

Antibody response to A35 as indicator of MPXV infection/recovery

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