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Target intelligence / Profile preview
Monkeypox Virus Antigen B6 Protein (B6R)
- Target
- B6R
- Molecular classification
- Glycoprotein, Viral Antigen
01
Overview
The Monkeypox virus antigen B6 protein (B6R) is a glycoprotein encoded by the monkeypox virus (MPXV). It is essential for efficient viral spread, involved in EEV formation, and regulates host complement system evasion. B6R is a major target for neutralizing antibodies and is used as a diagnostic marker for MPXV detection and a component in experimental vaccines. Human monoclonal antibodies targeting B6 show broad binding across orthopoxviruses and potent neutralization activity.
- Other names
- Monkeypox Virus Antigen B6MPXV-B6MPXV-B6R
02
Mechanism of action
Neutralization of viral infectivity; blocking viral entry/spread
03
Biological functions
Viral spread facilitationImmune evasionComplement regulationEEV formation
04
Disease associations
InfectionMonkeypox
05
Safety considerations
Potential for off-target effects with antibody-based therapiesLimited efficacy of single-antigen vaccines
06
Interacting drugs
Monoclonal Antibodies targeting B6
1 more in the full profile.
07
Biomarkers
B6 protein levels for diagnostic purposes
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