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Target intelligence / Profile preview
Monkeypox Virus Antigen H3 (H3L)
- Target
- H3L
- Molecular classification
- Glycoprotein, Envelope protein
01
Overview
Monkeypox virus antigen H3 (H3L protein) is a major envelope glycoprotein on the surface of the monkeypox virus. It mediates viral adhesion and entry into host cells by binding to cell-surface heparan sulfate. H3 is a major antigenic target recognized by both humoral and cellular immune responses, eliciting strong antibody responses and T-cell interferon responses. Monoclonal antibodies against H3 can neutralize MPXV in vitro and protect animals from lethal poxvirus challenge. It is used in rapid diagnostic assays and is a vaccine candidate due to its strong immunogenicity and conservation across orthopoxviruses.
- Other names
- H3 proteinh3l proteinMonkeypox virus envelope glycoprotein
02
Mechanism of action
Neutralization of viral entry via antibody binding, inhibition of heparan sulfate binding
03
Biological functions
Viral adhesionViral entryHeparan sulfate bindingImmune response elicitation
04
Disease associations
InfectionMonkeypox
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