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Target intelligence / Profile preview
Monkeypox Virus Antigen H3 Protein (H3L)
- Target
- H3L
- Molecular classification
- Viral Envelope Protein, Antigen, Chordopoxvirinae protein H3 family
01
Overview
The Monkeypox virus (MPXV) H3 protein, also known as the H3L protein, is a major envelope antigen found on the surface of the mature virion (MV) form of MPXV. It plays a critical role in viral attachment to host cells and mediates infection by binding to specific cell-surface molecules, notably heparan sulfate. The H3 protein is highly immunogenic and serves as a key target for both humoral and cellular immune responses during infection or vaccination. Recombinant forms of the MPXV-H3L protein are used as antigens in rapid diagnostic assays. Anti-H3L mAbs have potential therapeutic applications due to their neutralizing activity against live virus.
- Other names
- H3L proteinhmpxv_H03hmpxv_H03l
02
Mechanism of action
Neutralization of viral entry by monoclonal antibodies targeting H3L.
03
Biological functions
Viral attachment to host cellsMediation of viral entryImmune response elicitationHeparan sulfate binding
04
Disease associations
InfectionMonkeypox
05
Safety considerations
Potential for immune evasion through mutationsCross-reactivity with other orthopoxviruses
06
Biomarkers
Anti-H3L antibody levelsH3L antigen detection
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