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Target intelligence / Profile preview
Monoacylglycerol Lipase (MGLL)
- Target
- MGLL
- Molecular classification
- Enzyme, Serine Hydrolase, AB hydrolase superfamily
01
Overview
Monoacylglycerol lipase (MGLL, also known as MAGL or MGL) is a membrane-associated serine hydrolase enzyme that catalyzes the hydrolysis of monoacylglycerides into free fatty acids and glycerol. It plays a central role in lipid metabolism and endocannabinoid signaling. MGLL is abundantly expressed in tissues such as skeletal muscle, adipose tissue, and the brain, where it regulates energy homeostasis, pain perception, inflammation, and neuroprotection. Inhibition of MGLL is being explored as a therapeutic strategy for cancer and pain management.
- Other names
- Monoglyceride LipaseMGLMAGLHU-K5Lysophospholipase homolog/MAGL
02
Mechanism of action
Inhibition of monoacylglycerol hydrolysis, leading to increased levels of monoacylglycerols and decreased levels of free fatty acids.
03
Biological functions
Lipid metabolismEndocannabinoid system regulationHydrolysis of monoacylglyceridesEnergy homeostasis
04
Disease associations
Hallucinogen dependenceCannabis dependenceCancer progressionMetastasisPainInflammation
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