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Target intelligence / Profile preview
α/β-Hydrolase Domain-Containing 6 (ABHD6)
- Target
- ABHD6
- Molecular classification
- Enzyme, Lipase, α/β-hydrolase
01
Overview
α/β-Hydrolase Domain-Containing 6 (ABHD6) is a serine hydrolase enzyme that plays a crucial role in lipid metabolism by hydrolyzing monoacylglycerols, including 2-arachidonoylglycerol (2-AG), a key endocannabinoid. It is involved in regulating energy homeostasis, insulin secretion, and neurotransmission. ABHD6 is also implicated in cancer cell metabolism and inflammation, making it a promising therapeutic target for metabolic disorders and inflammatory diseases.
- Other names
- Monoacylglycerol lipase ABHD62-Arachidonoylglycerol hydrolase
02
Mechanism of action
Inhibition of ABHD6 leads to accumulation of its lipid substrates, which can modulate various signaling pathways, including cannabinoid receptor activation, insulin secretion improvement, and anti-inflammatory effects.
03
Biological functions
Regulation of endocannabinoid system2-Arachidonoylglycerol (2-AG) hydrolysisLipid metabolismRegulation of insulin secretionAMPA receptor traffickingEnergy homeostasisNeurotransmission
04
Disease associations
ObesityMetabolic syndromeCancerInflammationNeurological disorders
05
Safety considerations
Off-target effects of ABHD6 inhibitors need to be considered.Potential impact on lipid metabolism and energy homeostasis.
06
Interacting drugs
Specific inhibitors like WWL70, which target ABHD6 for therapeutic effects.
07
Biomarkers
None specifically defined, but circulating levels of bis(monoacylglycerol)phosphate (BMP) could serve as a biomarker for ABHD6 activity in metabolic contexts.
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