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Monoacylglycerol O-acyltransferase 2 (MGAT2)
- Target
- MGAT2
- Molecular classification
- Enzyme, Transferase, Acyltransferase, Glycosyltransferase
01
Overview
Monoacylglycerol O-acyltransferase 2 (MGAT2) is an enzyme involved in both lipid metabolism and protein glycosylation. In lipid metabolism, it catalyzes the conversion of monoacylglycerol (MAG) to diacylglycerol (DAG), a crucial step in triglyceride synthesis and dietary fat absorption, particularly in the small intestine. There is also a protein referred to as N-acetylglucosaminyltransferase II involved in N-glycan biosynthesis.
- Other names
- MGAT2CDG2ACDGS2GLCNACTIIGNT-IIGNT2Mannosyl (alpha-1,6)-glycoprotein beta-1,2-N-acetylglucosaminyltransferaseAlpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
02
Mechanism of action
Inhibition of monoacylglycerol to diacylglycerol conversion, reduction of triglyceride synthesis
03
Biological functions
Triglyceride synthesisDietary fat absorptionProtein N-glycosylationLipid metabolism
04
Disease associations
ObesityMetabolic syndromeCarbohydrate-deficient glycoprotein syndrome type II (CDG-II)Type 2 diabetesFatty liver disease
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